告知标题：Microphysiological Systems for Emulating Human Tissues and Diseases报 告 人：张宇先生（Y. Shrike Zhang）大学生，佐治亚理教院法大学（Harvard Medical School）报告时间：二〇一八年四月四日早晨9:00告诉地点：制浆造纸工程国家根本实验室306开会地点招待广大师生前往!轻工科学与工程高校二零一八年三月12日告知内容：Microphysiological systems are microfluidic three-dimensional miniature human tissue and organ models that recapitulate the important biological and physiological parameters of their in vivo counterparts. They have recently emerged as a viable platform for personalized medicine and drug screening. These biomimetic organoids are anticipated to replace the conventional planar, static cell cultures, and to bridge the gaps between the current pre-clinical animal models and the human body. In addition, multiple organoids may be channeled together through the microfluidics in a similar manner they arrange in vivo, providing the capacity to analyze interactions among these models. In this talk, I will discuss our recent efforts on developing integrated multi-organ-on-a-chip platforms formed by sophisticated microfluidics and bioengineered organoids, which can operate in a continual and automated manner over extended periods. I will also discuss a series of bioprinting strategies including sacrificial bioprinting, microfluidic bioprinting, and multi-material bioprinting, along with various cytocompatible bioink formulations, for the fabrication of biomimetic organoids. These platform technologies will likely provide new opportunities in constructing functional tissue and disease models with a potential extension into clinical therapeutics and precision therapy.报告人简要介绍：Dr. Zhang received a B.Eng. in Biomedical Engineering from Southeast University, China in 2010, after which he then obtained a M.S. in Biomedical Engineering from WashingtonUniversity in St. Louis and a Ph.D. in Biomedical Engineering at Georgia Institute of Technology and Emory University School of Medicine . Dr. Zhang then pursued postdoctoral training at Brigham and Women’s Hospital, Harvard Medical School, Harvard-MIT Division of Health Sciences and Technologies, and Wyss Institute for Biologically Inspired Engineering. (www.shrikezhang.comState of QatarDr. Zhang is currently a Research Faculty at Harvard Medical School and Associate Bioengineer at the Brigham and Women’s Hospital. His research is focused on innovating medical engineering technologies, including 3D bioprinting, organs-on-chips, microfluidics, biomedical imaging, and biosensing, to recreate functional tissues and their biomimetic models. In collaboration with a multidisciplinary team encompassing biomedical, mechanical, electrical, and computer engineers as well as biologists and clinicians, his laboratory seeks to ultimately translate these cutting-edge technologies into the clinics. He is an author of >120 publications and his scientific contributions have been recognized by >40 international, national, and regional awards. More information can be found on his website.