关于举行哈佛大学医学院张宇博士学术报告的通

报告题目:Microphysiological Systems for Emulating Human Tissues and Diseases报 告 人:张宇(Y. Shrike Zhang)博士,哈佛大学医学院(Harvard Medical School)报告时间:2018年8月30日 上午9:00报告地点:制浆造纸工程国家重点实验室306会议室欢迎广大师生前往!轻工科学与工程学院2018年8月22日报告内容:Microphysiological systems are microfluidic three-dimensional miniature human tissue and organ models that recapitulate the important biological and physiological parameters of their in vivo counterparts. They have recently emerged as a viable platform for personalized medicine and drug screening. These biomimetic organoids are anticipated to replace the conventional planar, static cell cultures, and to bridge the gaps between the current pre-clinical animal models and the human body. In addition, multiple organoids may be channeled together through the microfluidics in a similar manner they arrange in vivo, providing the capacity to analyze interactions among these models. In this talk, I will discuss our recent efforts on developing integrated multi-organ-on-a-chip platforms formed by sophisticated microfluidics and bioengineered organoids, which can operate in a continual and automated manner over extended periods. I will also discuss a series of bioprinting strategies including sacrificial bioprinting, microfluidic bioprinting, and multi-material bioprinting, along with various cytocompatible bioink formulations, for the fabrication of biomimetic organoids. These platform technologies will likely provide new opportunities in constructing functional tissue and disease models with a potential extension into clinical therapeutics and precision therapy.报告人简介:Dr. Zhang received a B.Eng. in Biomedical Engineering from Southeast University, China in 2008, after which he then obtained a M.S. in Biomedical Engineering from Washington University in St. Louis and a Ph.D. in Biomedical Engineering at Georgia Institute of Technology and Emory University School of Medicine . Dr. Zhang then pursued postdoctoral training at Brigham and Women’s Hospital, Harvard Medical School, Harvard-MIT Division of Health Sciences and Technologies, and Wyss Institute for Biologically Inspired Engineering. (www.shrikezhang.com)Dr. Zhang is currently a Research Faculty at Harvard Medical School and Associate Bioengineer at the Brigham and Women’s Hospital. His research is focused on innovating medical engineering technologies, including 3D bioprinting, organs-on-chips, microfluidics, biomedical imaging, and biosensing, to recreate functional tissues and their biomimetic models. In collaboration with a multidisciplinary team encompassing biomedical, mechanical, electrical, and computer engineers as well as biologists and clinicians, his laboratory seeks to ultimately translate these cutting-edge technologies into the clinics. He is an author of >120 publications and his scientific contributions have been recognized by >40 international, national, and regional awards. More information can be found on his website.

广大师生:为活跃学校的学术氛围,鼓励和支持学校教师邀请国内外知名专家进行广泛的学术交流活动。现继续开展“木棉花开”新材料讲坛活动,本次论坛的具体安排如下:一、论坛时间2018年7月5日14:30-17:00二、报告地点B12楼410会议室三、论坛议程14:30-14:40 系领导欢迎致辞14:40-15:30 王红军教授 ‘Multiscale and multifunctional fibrous matrix for skin grafts’(40min 报告,10min 提问)15:30-15:50 毛葱助理研究员 ‘微纳米生物活性玻璃复合材料调控难愈创面修复与再生’(15min 报告, 5min 提问)15:50-16:00 茶歇16:00-16:20 施雪涛教授 ‘3D打印增强型GelMA水凝胶支架及其功能化研究’(15min 报告, 5min 提问)16:20-16:40 董华教授 ‘精确调控生物分子分布及功能的微图案化电纺纳米纤维’(15min 报告,5min 提问)16:40-17:00 自由讨论欢迎广大师生参加!材料科学与工程学院2018年7月2日报告人简介:王红军教授Name: Hongjun WangInstitution: Department of Biomedical Engineering,Stevens Institute of Technology, New Jersey, USAEmail: hongjun.wang@stevens.eduLab webpage: www.stevens.edu/wanglabDr. Hongjun Wang is Professor of Biomedical Engineering and Professor of Chemistry and Chemical Biology at the Stevens Institute of Technology, Hoboken, New Jersey, USA. The research interests of the Wang lab (www.stevens.edu/wanglab) mainly focus on biomimetic materials design, 3D tissue reconstruction, in vitro tissue-on-a-chip and nanomedicine. His group has contributed a dozen of book chapters and invited reviews, a number of patent applications, over 100 invited talks and seminars and more than 70 peer-reviewed papers in Advanced Materials, PNAS, ACS Nano and Biomaterials. He is also a recipient of several awards including Provost’s Award for Academic Entrepreneurship & Enterprise Development , New Jersey Innovators Award , Jess N. Davis Award for Excellent Research , Jess N. Davis Award for Exemplary Research , etc. Prior to joining Stevens, he was a research fellow at the Wellman Center for Photomedicine, Massachusetts General Hospital and the Department of Dermatology, Harvard Medical School, Boston. Dr. Wang received his 1st Doctorate in Polymer Chemistry & Physics with honors from the Institute of Polymer Chemistry, Nankai University, Tianjin, China. He then worked at a Dutch biomedical company, IsoTis NV, and received his 2nd Doctorate in Biomedical Engineering from the Institute for Biomedical Technology, University of Twente, Netherlands. His research has been funded by NIH, NSF and other agencies. 报告人简介:毛葱 助理研究员姓名:毛葱单位:温州医科大学附属第二医院、浙江省骨科学重点实验室Email:maocong@wmu.edu.cn实验室网址: of Florida医学院联合培养。研究专注于新型生物活性组织再生医用材料的研发,尤其是对难愈创面的再生修复。至今共发表SCI论文二十余篇,且多篇文章曾获封面文章和该年度最佳文章。主持浙江省科技厅项目、温州市科技计划项目、育英人才项目,并参与省重点研发项目及多项国家级课题。现为Advenced Drug Delivery Review、Acta biomaterialia、Advanced Healthcare Materials、J. Mater. Chem B等杂志审稿人。

报告题目Data-Driven Rational Biosynthesis Design: From Moleculesto Cell Factories报 告 人:胡黔楠 博士 中国科学院上海生命科学研究院研究员报告时间:2018年6月5日10:30 – 11:30 报告地点:华南理工大学大学城校区生物科学与工程学院B6-207欢迎广大师生踊跃参加!生物科学与工程学院2018年5月30日报告人简介:胡黔楠博士,中国科学院上海生命科学研究院研究员,计算生物学研究所细胞工厂设计研究组组长,科技部重点专项咨询委专家和指南评估专家,国家基金委杰青等项目评审专家。胡黔楠博士从事生物制造设计技术平台构建研究,创建了全球最大的生物制造产品数据库以及生物合成反应数据库,开发了数据驱动型一站式生物合成设计技术系统RxnFinder,打造了数据驱动型微生物细胞工厂研究新模式。在生物制造产品数据库、生物合成反应数据库、生物合成前体化合物挖掘、目标化合物选择、酶发现技术、生物合成途径设计、化合物生物合成潜力挖掘、微生物菌株优化、菌株理性选择、以及一站式设计技术集成等方面研究中作出了一系列原创性的工作。报告摘要:Microbial cell factories have a lot of important and promising applications in producing bulk chemicals, natural products, biofuels, and so on. The new bottleneck of microbial cell factory is how to design reaction, enzyme, and pathway, based on enormous biosynthesis data. Our team has been focused on the construction of data-driven biosynthesis design platform (www.rxnfinder.org), which is composed of the following sections: Biochemical reaction database (RxnFinder): our team manually curated more than 200,000 biochemical reactions, which are 10 times larger than the KEGG reactions, from more than 500,000 biosynthesis references retrieved from PubMed using more than 40 biosynthesis related keywords. More than 10 third party databases are linked, and more than 10 informatics methods are provided. Enzyme discovery (ECAssignment): a chemical transformation-based method (ECAssigner) is proposed for enzyme discovery using biochemical reaction difference fingerprints and reaction similarity. Biosynthetic pathway design (BioSynther): BioSynther tool was developed to design biosynthesis pathways between starting molecules and target molecules, in which users can interactively re-design biosynthetic pathways. One of the most promising applications of biosynthetic methods is to produce chemical products of high value from the ready-made chemicals. BioSynther is also developed to explore the biosynthetic potentials of precursor chemicals using BKM-react, Rhea, and more than 100,000 in house RxnFinder reactions manually curated. Cell -based pathway optimization platform (SynBioEcoli, EcoSynther, LifeSynther): Based on the comprehensive biosynthetic data curated above, whole-cell modelling methods are proposed to optimize heterogeneous biosynthetic pathways. The proposed data-driven one-stop informatics platform could be used as a useful tool in metabolic engineering, biosynthesis, and synthetic biology.

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